Effect of an Organophosphate Insecticide Diazinon on the Activity of Acetylcholinesterase and Lipid Peroxidation of a Common Carp, Cyprinus Carpio L

Diazinon is a widely used organophosphorus pesticide in agriculture and environmental health, hence its adverse effects on non target animals, especially on fish is to be determined. The present research is conducted to study the influence of diazinon [0, 0-diethyl 0-(2-isopropyl-6-methylpyrimidin-4yl) phosphorothioate] on acetylcholinestrase (AChE) and lipidperoxidation (LPO) on freshwater common carp (Cyprinus carpio L.). Adult fish (mean body weight 42.6±3.86 g and 19.1±2.66 cm mean length ) were divided into five groups with 3 replicates and subjected to 5 concentrations (100, 200, 300, 400 and 500 μg L) of diazinon for 30 days and compared with control (untreated) fish. Fishes were acclimatized to laboratory conditions for 7 days and then Physio-chemical characteristic of water was determined before the treatment. Induction of oxidative stress in various tissues was evidence of increased lipid peroxidation levels seems to be associated with the concentration of diazinon. Acetylcholinesterase activity responded positively in a concentration dependent pattern. It was concluded that LPO and AChE could be a valuable biomarker as an indicator of water pollution on aquatic ecosystems.